Privileged Diazepine Compounds and Their Emergence as Bromodomain Inhibitors
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Phosphotyrosine signaling is regulated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here we discuss the potential of vanadium derivatives as PTP enzyme inhibitors and metallotherapeutics. We describe how vanadate in the V oxidized state is thought to inhibit PTPs, thus acting as a pan-inhibitor of this enzyme superfamily. We discuss recent...
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This corrects the article DOI: 10.1038/cddis.2017.383.
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We propose to accelerate the rate of convergence of the pattern recognition task by directly minimizing the variance diameters of certain hypothesis spaces, which are critical quantities in fast-convergence results. We show that the variance diameters can be controlled by dividing hypothesis spaces into metric balls based on a new order metric. This order metric can be minimized as an ordinal r...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2014
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2014.03.004